Château Chasse-Spleen is the leading Moulis estate along with Château Poujeaux. Although it is classified only as a Cru Bourgeois, it regularly outperforms many of the Médoc's more renowned classed growths. There are two theories behind the château's rather unusual name: firstly, that, when Lord Byron visited the estate in 1821, he remarked `Quel remède pour chasser le spleen`. Secondly, it is named after BaudeChâteau Chasse-Spleenlaire's poem, Spleen.
Chasse-Spleen's wines were always noteworthy, though the quality improved dramatically with its acquisition by the Taillan Group, which also owns Château Haut-Bages-Libéral, in 1976. It was run by Bernadette Villars until she and her husband were killed in an accident while hiking in the Pyrénées in 1992. The property is now run by her daughter Claire.